Syphilis infection is associated with an increase in plasma viral load in HIV infected patients: results from the FHDH cohort — ANRS CO4
نویسندگان
چکیده
Methods In HIV-infected men followed in Paris between 1998 and 2006 in the FHDH cohort, we studied 2 matched groups of patients: the syphilis+ and syphilis-. The syphilis+ group consisted of men who were diagnosed with an incident primary or secondary syphilis during their HIV follow-up. Each syphilis+ patient was matched up to 5 men who did not contract syphilis (syphilis-) according to his age, sexuality, centre and date of syphilis diagnosis (index date), and to his immunologic and virologic status in the period prior to syphilis infection. We studied whether syphilis infection was associated with an increase in pVL in the 6 months following infection (rise of pVL ≥0.5 log or pVL ≥500 copies/mL in patients with prior undetectable pVL) by conditional logistic regression. Changes in CD4 cell counts were studied by linear mixed model.
منابع مشابه
Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort.
BACKGROUND Concomitant syphilis and human immunodeficiency virus (HIV) infection is increasingly frequent in industrialized countries. METHODS From a large hospital cohort of HIV-infected patients followed up in the Paris area between 1998 and 2006, we examined the effect of early syphilis on plasma HIV-1 RNA levels and CD4 cell counts. We compared 282 HIV-1-infected men diagnosed as having i...
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